The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
Biomedical Engineering; Biological Sciences; Chemistry and Biochemistry
US 20170281790 A1
Board of Trustees of the University of Arkansas (Fayetteville, AR)
Kumar, Thallapuranam Krishnaswamy Suresh; Zaharoff, David A.; Jayanthi, Srinivas; Koppolu, Bhanuprasanth; Kerr, Rebecca; Balachandran, Kartik; and McNabb, David S., "Engineered FGF compositions and methods of use thereof" (2019). Patents Granted. 357.