Peptides That Block Transmission Of Orthotospoviruses And Methods Of Using The Same

Inventors

Ioannis Tzanetakis, University of Arkansas, Fayetteville
Jing Zhou, University of Arkansas, Fayetteville

Document Type

Patent

Publication Date

3-7-2023

Abstract

Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.

Department

Entomology; Plant Pathology

Patent Number

US11597945

Application Number

US 20210071196 A1

Application Published

3-11-2021

Application Filed

6-26-2020

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Ioannis Tzanetakis, Department of Entomology and Plant Pathology
Jing Zhou, Department of Entomology and Plant Pathology

Citation

Tzanetakis, I., & Zhou, J. (2023). Peptides That Block Transmission Of Orthotospoviruses And Methods Of Using The Same. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/447