Document Type
Article
Publication Date
2-2024
Keywords
Giant Panda; commentary; microbiology
Abstract
In this study, we have successfully constructed a comprehensive database of metagenome-assembled genomes (MAGs) pertaining to the gut microbiota of the giant panda. Through our analysis, we have identified significant reservoirs of antibiotic resistance genes (ARGs), namely Escherichia coli, Citrobacter portucalensis, and Klebsiella pneumoniae. Furthermore, we have elucidated the primary contributors to ARGs, including Streptococcus alactolyticus and Clostridium SGBP116, in both captive and wild pandas. Additionally, our findings have demonstrated a higher prevalence of ARGs in the metagenome, with notable expression of the RPOB2 gene in S. alactolyticus. Crucially, 1217 ARGs shared homology with human gut ARGs, underscoring the interaction relationship between pandas and human microbiomes. These findings are instrumental in understanding the antibiotic resistance landscape in the giant panda's gut, providing a framework for developing strategies to combat antibiotic resistance and safeguard the health of this endangered species.
Citation
Deng, F., Han, Y., Huang, Y., Li, D., Chai, J., Deng, L., Wei, M., Wu, K., Zhao, H., Yang, G., Zhao, J., Li, Y., & Wang, C. (2024). A Comprehensive Analysis of Antibiotic Resistance Genes in the Giant Panda Gut. iMeta, 3 (1) https://doi.org/10.1002/imt2.171
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
