Date of Graduation
5-2015
Document Type
Thesis
Degree Name
Bachelor of Science
Degree Level
Undergraduate
Department
Biological Sciences
Advisor/Mentor
Rhoads, Douglas D.
Committee Member/Reader
Durdik, Jeannine
Committee Member/Second Reader
Zies, Brenda J.
Committee Member/Third Reader
Harriss, Edmund
Abstract
The Human FOXP3 gene plays a role in immunosuppression, which includes the suppression of the maternal immune system to allow the growth of a semi-foreign fetus inside her uterus. This has lead scientists to hypothesize that FOXP3 gene played a crucial role in the development of viviparous species. FOXP3 is highly conserved across Eutherian mammals, but the degree of conservation in other viviparous species has not been investigated. This study found that FOXP3 orthologs are much less highly conserved in aplacental species and may be more closely related to other members of the FOXP gene family than to the FOXP3 found in mammals. Through the creation of phylogenetic trees, I found that all of the members of the Forkhead Box Protein Family were named correctly, but FOXP3 had the highest degree of substitutions, which may explain its relatively novel function in immunosuppression.
Keywords
Immunosuppression; FOXP3; Viviparous species
Citation
Guffey, E. G. (2015). Evolutionary analysis of the genomic region of FOXP3 in vertebrates. Biological Sciences Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/biscuht/4
