Date of Graduation
5-2023
Document Type
Thesis
Degree Name
Bachelor of Science in Biology
Degree Level
Undergraduate
Department
Biological Sciences
Advisor/Mentor
Harris, Leonard
Committee Member/Reader
Du, Yuchun
Committee Member/Second Reader
Catanzaro, Donald
Committee Member/Third Reader
Chapman, Kate
Abstract
Fanconi anemia (FA) is a rare genetic condition in which the cell’s DNA repair machinery is dysregulated, significantly increasing the chances of tumorigenesis. Further research is being done in order to improve patient outcomes and incidences of cancer. Our group created a computational model of the FA DNA repair gene network, which removes interstrand crosslinks found in damaged DNA and repairs it so DNA synthesis can continue. Computer simulations show the number of DNA damage indicators decreased as the pathway continued. This was expected as the FA pathway repairs DNA damage. The goal of this project was to provide further understanding of the protein interactions so that other biologically significant pathways may be added in the future.
Keywords
Fanconi anemia, Computational modeling, Cancer, Nucleotide excision repair
Citation
Warren-Belford, A. (2023). Computational Modeling of the Fanconi Anemia Gene Network and its Connection to Cancer. Biological Sciences Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/biscuht/84