Visible light mediated intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes

Authors

Theresa H. Nguyen, University of Arkansas, Fayetteville
Soumitra Maity, University of Arkansas, Fayetteville
Nan Zheng, University of Arkansas, FayettevilleFollow

Document Type

Article

Publication Date

2014

Keywords

[3+2], Alkyne, Annulation, Cyclopropylaniline, Photoredox catalysis, Visible light

Abstract

Intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes is realized using visible light photoredox catalysis, yielding a variety of cyclic allylic amines in fair to good yields. This method exhibits significant group tolerance particularly with heterocycles. It can also be used to prepare complex heterocycles such as fused indolines.

Comments

Principal Investigator: Nan Zheng

Acknowledgements: This publication was supported by the University of Arkansas, Arkansas Bioscience Institute, Grant Number P30 GM103450 from the National Institute of General Medical Sciences of the National Institutes of Health (NIH), NSF Career Award under Award Number CHE-1255539.

Citation

Nguyen, T. H., Maity, S., & Zheng, N. (2014). Visible light mediated intermolecular [3 + 2] annulation of cyclopropylanilines with alkynes. Journal of Organic Chemistry, 10, 975-980. https://doi.org/10.3762/bjoc.10.96

Creative Commons License

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