Date of Graduation
5-2023
Document Type
Thesis
Degree Name
Bachelor of Science in Chemistry
Degree Level
Undergraduate
Department
Chemistry & Biochemistry
Advisor/Mentor
Thallapuranam, Suresh
Committee Member/Reader
Adams, Paul
Committee Member/Second Reader
Castro Salas, Raquel
Abstract
A novel chimera protein, consisting of the C-terminus of Fibroblast Growth Factor (FGF) 21 and super FGF1, a mutant of the wild-type FGF1, was studied. The protein retained the stability of sFGF1 and the endocrine acting behaviors and binding efficiency of FGF21, so that it could be more practical for therapeutic uses as a wound healing and angiogenic agent. sFGF1- FGF21 was expressed and purified before utilizing various biophysical techniques to measure its stability, secondary and tertiary characteristics, and metabolic activity.
Keywords
fibroblast growth factor, chimera protein characterization
Citation
Armstrong, S. (2023). Design of a Hyperstable Endocrine Acting Fibroblast Growth Factot. Chemistry & Biochemistry Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/chbcuht/44