Dysregulation of the muscle clock during development of cancer cachexia

Authors

Madeline Amos, University of Arkansas, Fayetteville

Files

Description

INTRODUCTION
Cancer continues to be one of the leading causes of death across the world. Among many conditions that accompany cancer, cachexia is one that has long been identified as an unfortunate consequence. Cachexia is a skeletal muscle-wasting syndrome that ultimately leads to deterioration in the body’s functional ability and is considered to be irreversible solely by nutritional means. Researchers have yet to identify the precise mechanisms responsible for its development and current treatments remain inadequate.

PURPOSE
The purpose of this study was to confirm the dysregulation of Clock gene expression in male and female tumor-bearing mice, whether such effects can be recapitulated in an invitro model of cancer cachexia.

Publication Date

2021

Publisher

College of Education and Health Professions Honors Program

City

Fayetteville

Keywords

Research-Based

Disciplines

Medicine and Health Sciences | Nutritional and Metabolic Diseases

Comments

Advisors:

Tyrone Washington, Ph.D.
Nicholas Greene, Ph.D.

Citation

Amos, M. (2021). Dysregulation of the muscle clock during development of cancer cachexia. 2021 Honors Symposium. Retrieved from https://scholarworks.uark.edu/coesym21/22