Date of Graduation
12-2023
Document Type
Thesis
Degree Name
Master of Science in Biomedical Engineering (MSBME)
Degree Level
Graduate
Department
Biomedical Engineering
Advisor/Mentor
Younghye Song
Committee Member
Nelson, Christopher
Second Committee Member
Balachandran, Kartik
Keywords
Breast Cancer, Spinal Cord Injury, Tissue Engineering
Abstract
Neuron infiltration is involved in a multitude of diseased states and is critical in the regeneration of physiologic conditions. Modeling of innervation in three-dimensional, heterogenous, environments would allow early investigation in the crosstalk of neurons and native cells in normal and pathophysiologic microenvironments to gain an understanding of mechanistic functions. This would allow for greater insight into the role of metabolism, cell adhesion, microenvironmental alternations, cellular crosstalk, and signaling pathways that play a role in the promotion and prevention of neurite growth. In this thesis, with the construction of collagen-based hydrogels as the foundation for cell culture, we investigate cell behavior in models that mimic native tissue microenvironments where neurite infiltration contributes to pathophysiology.
Citation
Ala-Kokko, N. (2023). Tissue-Engineered Models for Investigating Nerve Infiltration in Fibrotic Microenvironments. Graduate Theses and Dissertations Retrieved from https://scholarworks.uark.edu/etd/5178
Included in
Bioelectrical and Neuroengineering Commons, Biomedical Devices and Instrumentation Commons, Molecular, Cellular, and Tissue Engineering Commons