Date of Graduation

8-2025

Document Type

Dissertation

Degree Name

Doctor of Philosophy in Engineering (PhD)

Degree Level

Graduate

Department

Biomedical Engineering

Advisor/Mentor

Jorge Almodovar

Committee Member

Wolchok, Jeffrey

Second Committee Member

Powell, Jeremy

Third Committee Member

Balanchandran, Kartik

Fourth Committee Member

Muldoon, Timothy

Keywords

Animal welfare; Drug delivery; Microoneedle; Pain management

Abstract

Veterinary medicine requires innovative drug delivery strategies to enhance therapeutic efficacy while minimizing stress and handling. This dissertation explores the development and application of biodegradable microneedle patches for the transdermal delivery of meloxicam in livestock, offering a minimally invasive alternative to traditional administration methods. The research investigates the fabrication and characterization of microneedles using polyvinyl alcohol, collagen, and chitosan blends, demonstrating their mechanical strength, biocompatibility, and ability to facilitate sustained drug release. In vitro and in vivo evaluations confirm effective skin penetration, dissolution, and localized drug delivery. Pharmacokinetic studies highlight anatomical site-dependent variations in drug absorption, emphasizing the need for strategic placement to optimize systemic bioavailability. Additionally, the limited solubility of MEL is identified as a key factor influencing drug uptake, prompting consideration of solubility-enhancing approaches. Beyond technical validation, this work explores the translational potential of microneedle technology in veterinary pain management, addressing challenges such as regulatory compliance, market adoption, and economic feasibility. Findings underscore the potential of microneedle patches to improve livestock welfare and streamline drug administration practices. Future research should focus on optimizing formulation strategies, expanding therapeutic applications, and advancing commercialization efforts to integrate this technology into routine veterinary care.

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