Author ORCID Identifier:

https://orcid.org/0009-0006-6418-2589

Date of Graduation

7-2026

Document Type

Thesis

Degree Name

Master of Science in Food Science (MS)

Degree Level

Graduate

Department

Food Science

Advisor/Mentor

Lee, Sun-Ok

Committee Member

Ubeyitogullari, Ali

Second Committee Member

Robinson, Samantha

Keywords

Caco-2 cell; Delivery system; Encapsulation; Porous starch; Resveratrol; Transport

Abstract

Resveratrol (Res) is a polyphenolic compound found in grapes, red wine, and berries, with health benefits such as antioxidant, anti-inflammatory, and cardioprotective properties. The poor stability and bioaccessibility of Res after consumption by humans require the development of delivery systems. Among many delivery systems, porous starch (PS) is a safe, cost-effective, and high in adsorption capacity encapsulation material for drugs and bioactive compounds sensitive to environmental factors like light and heat. Porous rice, corn, and potato starch have different granule sizes, pore volumes, and surface areas. However, the impact of these encapsulation capabilities remains unclear among the three porous starches. Therefore, this study aims to evaluate the loading capacity, in vitro bioaccessibility, and cellular transport percentage of Res among porous rice, corn, and potato starch. Res was encapsulated into PS using ultrasonication, and the loading capacity was analyzed; in vitro simulated digestion was conducted to evaluate the bioaccessibility; cellular transport assay was performed using Caco-2 cell culture models to measure Res transport percentage. Among the three PS, rice and corn starch had higher Res loading capacity (3.6 ± 0.4 % and 3.5 ± 0.6 %, respectively) compared to potato starch (1.8 ± 0.2 %). After simulated digestion, corn and potato starch showed higher bioaccessibility (78.0 ± 0.9 % and 79.6 ± 1.4 %, respectively) compared to rice starch (71.0 ± 3.0 %). All three porous starches achieved high total Res transport (56 – 68 %), with rice and potato showing significantly higher transport percentage compared to corn throughout the cellular transport assays. In conclusion, while the unique structural differences of all three porous starches influence their individual encapsulation capacities, porous rice and potato starches, compared to porous corn starch, can also serve as highly effective delivery systems that significantly enhance the cellular transport of Res.

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