Document Type

Patent

Publication Date

8-19-2014

Abstract

Peptoids capable of inhibiting or reversing amyloid .beta. (A.beta.) fibril or plaque production are described. The peptoids form a helical structure with three monomers per helical turn and have at least two monomers with a side-chain having an arylalkyl group having the same chirality positioned such that the side-chains are on the same side of the peptoid. Methods of using the peptoids to inhibit or reverse aggregation of A.beta of treating subjects with Alzheimer's disease (AD) or slowing the progression of AD are also provided.

Department

Chemical Engineering

Patent Number

US8809275

Application Number

US20130102539

Application Published

4-25-2013

Application Filed

10-19-2012

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR); University of South Carolina (Columbia, SC)

Comments

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with United States government support awarded by the National Institutes of Health grant number 1P30RR031154-02 from the National Center for Research Resources. The United States may have certain rights in this invention.

Shannon Servoss, Department of Chemical Engineering, University of Arkansas, Fayetteville, AR

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