Provided herein are vaccine vectors including an antigenic polypeptide and an HMGB 1 polypeptide present on the surface of the vaccine vector. Compositions comprising the vaccine vectors are also provided and include a pharmaceutically acceptable carrier, suitably a carrier for oral or nasal administration. Also provided are methods of enhancing immune responses, in particular antibody immune response and suitably an IgA response, by administering the vaccine vectors or compositions disclosed herein to a subject.
Texas A&M University System (College Station, TX); Board of Trustees of the University of Arkansas (Little Rock, AR)
Berghman, L., Bottje, W. G., Hargis, B. M., & Layton, S. (2014). Vaccine vectors and methods of enhancing immune responses. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/295