Cleavage resistant photoluminescent proteins and applications thereof

Inventors

Robert Beitle Jr., University of Arkansas, FayettevilleFollow
Rudra Palash Mukherjee, University of Arkansas, FayettevilleFollow
Thallapuranam Krishnaswamy Suresh Kumar, University of Arkansas, FayettevilleFollow
Joshua Sakon, University of Arkansas, FayettevilleFollow
David S. McNabb, University of Arkansas, FayettevilleFollow

Document Type

Patent

Publication Date

10-15-2019

Abstract

Photoluminescent proteins resistant to protein cleavage reagents are described herein. In being resistant to cleavage reagents, such photoluminesncent proteins can reduce the number of digestion or cleavage products, thereby simplifying quantification and purification of recombinant protein compositions. In some embodiments, a photoluminescent protein described herein comprises an amino acid sequence having an absence of internal methionine residues.

Department

Biological Sciences; Chemical Engineering; Chemistry & Biochemistry

Patent Number

US10442842

Application Number

US 20170253640 A1

Application Published

9-7-2017

Application Filed

3-2-2017

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Robert Beitle, Jr., Department of Chemical Engineering, University of Arkansas, Fayetteville, AR
Rudra Palash Mukherjee, Department of Chemical Engineering, University of Arkansas, Fayetteville, AR
Thallapuranam Krishnaswamy Suresh Kumar, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
David S. McNabb, Department of Biological Sciences, University of Arkansas, Fayetteville, AR

Citation

Beitle, R., Mukherjee, R., Kumar, T., Sakon, J., & McNabb, D. S. (2019). Cleavage resistant photoluminescent proteins and applications thereof. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/381