Date of Graduation
12-2021
Document Type
Thesis
Degree Name
Bachelor of Science in Biomedical Engineering
Degree Level
Undergraduate
Department
Biomedical Engineering
Advisor/Mentor
Wolchok, Jeffrey
Abstract
Volumetric muscle loss (VML) injuries are prevalent in both military personnel suffering from battlefield related incidents, and civilians following severe motor accidents. Despite its prevalence, VML has no pro-regenerative clinical treatments in place to recover some of the functional capabilities of the damaged muscle. Free flap grafting, debridement of damaged tissue, and physical therapy are the only clinical standards available that offer little functional recovery benefits, even after years of consistent treatment. In this study, anti-inflammatory cytokine interleukin-10 in conjunction with autologous minced muscle was assessed as a possible treatment for VML injuries and its influences on cellular behavior within the wound site.
Keywords
VML, IL-10, Treg, Macrophages, Muscle Injury, Muscle Regeneration
Citation
Blackwell, Z. (2021). Effects of IL-10 On Local Cell Populations and Functional Recovery Following VML Injury. Biomedical Engineering Undergraduate Honors Theses Retrieved from https://scholarworks.uark.edu/bmeguht/110
Included in
Biomedical Engineering and Bioengineering Commons, Medical Biotechnology Commons, Occupational Therapy Commons, Surgery Commons, Trauma Commons