Patents from 2025
Elastically Deformable Components And Assemblies For Use In Cellular Assays, Kartik Balachandran and Nasya Moriah Sturdivant
Patient Specific Medical Balloon Forming Machine And System, Maxwell Bean, Morten O. Jensen, Barry Uretsky, and Kaitlyn M. Elmer
Publications from 2024
Optimizing Recombinant Cas9 Expression: Insights from E. coli BL21(DE3) Strains for Enhanced Protein Purification and Genome Editing, Shilpi Agrawal, Made Harumi Padmaswari, Abbey L. Stokes, Daniel Maxenberger, Morgan Reese, Adila Khalil, and Christopher E. Nelson
Development of Tissue-Engineered Model of Fibrotic Scarring after Spinal Cord Injury to Study Astrocyte Activation and Neurite Outgrowth In Vitro, Nikolas Ala-Kokko, Inha Baek, and Younghye Song
Simultaneous Modulation of Pulse Charge and Burst Period Elicits Two Differentiable Referred Sensations, T. R. Benigni, A. E. Pena, S. S. Kuntaegowdanahalli, J. J. Abbas, and R. Jung
Scaffold-Free Development of Multicellular Tumor Spheroids with Spatial Characterization of Structure and Metabolic Radial Profiles, Shelby N. Bess, Gaven K. Smart, Matthew J. Igoe, and Timothy J. Muldoon
Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections, Erin E. Drewke, Robert L. Brand, Caroline G. Geels, Hanna K. Jensen, Kevin Wong, Jarret D. Sanders, and Narasimhan Rajaram
Liquid Crystalline Collagen Assemblies as Substrates for Directed Alignment of Human Schwann Cells, Homa Ghaiedi, Luis Carlos Pinzon-Herrera, Saja Alshafeay, Leonard Harris, Jorge Almodovar, and Karthik Nayani
Advancing CRISPR-Based Solutions for COVID-19 Diagnosis and Therapeutics, Roaa Hadi, Abhishek Poddar, Shivakuma Sonnaila, Venkata Suryanarayana Murthy Bhavaraju, and Shilpi Agrawal
Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy, Varsha Karunakaran, Sina Dadgar, Santosh K. Paidi, April Mordi, Whitney A. Lowe, Umme Marium Mim, Jesse D. Ivers, Joel Rodriguez Troncoso, Jared A. McPeake, Alric Fernandes, Sanidhya D. Tripathi, Ishan Barman, and Narasimhan Rajaram
Phenotypic and Functional Characterization of Bovine Adipose-Derived Mesenchymal Stromal Cells, Vitali V. Maldonado, Sriya Pokharel, Jeremy G. Powell, and Rebekah M. Samsonraj Dr.
Precision and Efficacy of RNA-guided DNA Integration in High-Expressing Muscle Loci, Made Harumi Padmaswari, Gabrielle Bulliard, Shilpi Agrawal, Mary S. Jia, Sabin Khadgi, Kevin A. Murach, and Christopher E. Nelson
In vivo Measurement of Nadh Fluorescence Lifetime in Skeletal Muscle via Fiber-Coupled Time-Correlated Single Photon Counting, Kathryn M. Priest, Jacob V. Schluns, Nathania Nischal, Colton L. Gattis, Jeffery C. Wolchok, and Timothy J. Muldoon
Resistance to Acetyl Coenzyme A Carboxylase (ACCase) Inhibitor in Lolium multiflorum: Effect of Multiple Target-Site Mutations, Gulab Rangani, Ana Claudia Langaro, Shilpi Agrawal, Reiofeli Algodon Salas-Perez, Juan Camilo Velasquez, Christopher E. Nelson, and Nilda Roma-Burgos
Recovery of Ionic Liquid from the Model Solution Mixture Mimicking the Catalytically Hydrolyzed Cellulose Product Utilizing Amberlyst Ion-Exchange Resin, Chhabilal Regmi, Chidambaram Thamariselvan, Zhexi Zhu, Xianghong Qian, and S. Ranil Wickramasinghe
Immersive Virtual Reality-Based Learning as a Supplement for Biomedical Engineering Labs: Challenges Faced and Lessons Learned, Ishita Tandon, Vitali Maldonado, Megan Wilkerson, Amanda Walls, Raj R. Rao, and Mostafa Elsaadany
Accelerating Neurotechnology Development Using an Agile Methodology, Anil Kumar Thota and Ranu Jung
Identifying and Training Deep Learning Neural Networks on Biomedical-Related Datasets, Alan E. Woessner, Usman Anjum, Hadi Salman, Jacob Lear, Jeffrey T. Turner, Ross Campbell, Laura Beaudry, Justin Zhan, Lawrence E. Cornett, Susan Gauch, and Kyle P. Quinn
Photodegradation of Microplastics through Nanomaterials: Insights into Photocatalysts Modification and Detailed Mechanisms, Yiting Xiao, Yang Tian, Wenbo Xu, and Jun Zhu
Publications from 2023
Co-activation of the Diaphragm and External Intercostal Muscles through an Adaptive Closed-loop Respiratory Pacing Controller, Rabeya Zinnat Adury, Ricardo Siu, and Ranu Jung
Autofluorescence Imaging of Endogenous Metabolic Cofactors in Response to Cytokine Stimulation of Classically Activated Macrophages, Shelby N. Bess, Matthew J. Igoe, Abby C. Denison, and Timothy J. Muldoon
Design, Fabrication, and Evaluation of 3-D-printed Cystotomy Spoons as a Retrieval Method in Dogs, Davina C. D'Angelo, Sam E. Stephens, Morten O. Jensen, and Lauren R. Thomas
Mitochondrial Transfer from Cancer-associated Fibroblasts Increases Migration in Aggressive Breast Cancer, Kevin F. Gwolas, Sarah Libring, Emily Berestesky, Shayan Gholizadeh, Samantha C. Schwager, Andra R. Frost, Thomas R. Gaborski, Jian Zhang, and Cynthia A. Reinhart-King
Local IL-10 Delivery Modulates the Immune Response and Enhances Repair of Volumetric Muscle Loss Muscle Injury, Tai Huynh, Cassandra Reed, Zain Blackwell, Peyton Phelps, Luis Carlos Pinzon-Herrera, Jorge Almodovar, David A. Zaharoff, and Jeffery Wolchok
A Biochemical Necroptosis Model Explains Cell-type-specific Responses to Cell Death Cues, Geena V. Ildefonso, Marie Oliver Metzig, Alexander Hoffmann, Leonard A. Harris, and Carlos F. Lopez
Integrated Electrocoagulation, Ultrafiltration, Membrane Distillation, and Crystallization for Treating Produced Water, Mahmood Jebur, Yelyzaveta Bachynska, Xiaolei Hao, and Sumith Ranil Wickramasinghe
PINE-TREE enables efficient enrichment of prime-edited hPSCs, Mary S. Jia and Christopher E. Nelson
Early Introduction of 3D Modeling Modules Promotes the Development of Simulation Skills in Downstream Biomedical Engineering Curricula, Mary S. Jia, Raj R. Rao, and Mostafa Elsaadany
Clinical Utility of Mesenchymal Stem/stromal Cells in Regenerative Medicine and Cellular Therapy, Vitali V. Maldonado, Neel H. Patel, Emma E. Smith, C. Lowry Barnes, Michael P. Gustafson, Raj R. Rao, and Rebekah M. Samsonraj
Induced Pluripotent Stem Cells Derived from Patients Carrying Mitochondrial Mutations Exhibit Altered Bioenergetics and Aberrant Differentiation Potential, Fibi Meshrkey, Kelly M. Scheulin, Christopher M. Littlejohn, Joshua Stabach, Bibhuti Saikia, Vedant Thorat, Yimin Huang, Thomas LaFramboise, Edward J. Lesnefsky, Raj R. Rao, Franklin D. West, and Shilpa Iyer
Contactless system and method for assessing tissue viability and other hemodynamic parameters, Michele Pierro, Kyle Quinn, and Alan Woessner
Transcriptome Profiling of a Synergistic Volumetric Muscle Loss Repair Strategy, Kevin Roberts, John Taehwan Kim, Jacob Schluns, Grady Dunlap, Jamie Hestekin, and Jeffery Wolchok
Evaluating Differences in Optical Properties of Indolent and Aggressive Murine Breast Tumors Using Quantitative Diffuse Reflectance Spectroscopy, Joel Rodriguez Troncoso, Umme Marium Mim, Jesse D. Ivers, Santosh K. Paidi, Mason G. Harper, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, David A. Zaharoff, Ishan Barman, and Narasimhan Rajaram
Publications from 2022
Anesthetics Affect Peripheral Venous Pressure Waveforms and the Cross-talk with Arterial Pressure, Ali Z. Al-Alawi, Kaylee R. Henry, Lauren D. Crimmins, Patrick C. Bonasso, Md Abul Hayat, Melvin S. Dassinger, Jeffrey M. Burford, Hanna K. Jensen, Joseph Sanford, Jingxian Wu, Kevin W. Sexton, and Morten O. Jensen
Macrophage-targeted Anti-CCL2 Immunotherapy Enhances Tumor Sensitivity to 5-fluorouracil in a Balb/c-CT26 Murine Colon Carcinoma Model Measured Using Diffuse Reflectance Spectroscopy, Shelby N. Bess, Gage J. Greening, Narasimhan Rajaram, and Timothy J. Muldoon
Minimally Invasive in vivo Endoscopic Monitoring of Dextran Sulfate Sodium-induced Murine Colitis, Elizabeth A. Bullard, Ariel I. Mundo, Shelby N. Bess, Kathryn Miller Priest, and Timothy J. Muldoon
Biodegradable Microneedle Patch for Delivery of Meloxicam for Managing Pain in Cattle, David A. Castilla-Casadiego, Katherine A. Miranda-Munoz, Jesse L. Roberts, Anne D. Crowell, David Gonzalez-Nino, Dipankar Choudhury, Frank O. Aparicio-Solis, Shannon L. Servoss, Adrianne M. Rosales, Gary Prinz, Min Zou, Yuntao Zhang, Johann F. Coetzee, Lauren F. Greenlee, Jeremy Powell, and Jorge Almodovar
Electrospun Hydrophobic Interaction Chromatography (HIC) Membranes for Protein Purification, Shu-Ting Chen, Sumith Ranil Wickramasinghe, and Xianghong Qian
Functional Analysis of the Cortical Transcriptome and Proteome Reveal Neurogenesis, Inflammation, and Cell Death after Repeated Traumatic Brain Injury In vivo, Celeste Dunn, Lais A. Ferreira, Sara M. Venier, Syed F. Ali, Jeffery Wolchok, and Kartik Balachandran
Exploring the Role of Metabolites in Cancer and the Associated Nerve Crosstalk, Inah Gu, Emory A. Gregory, Casey Atwood, Sun-Ok Lee, and Young Hye Song
Immunomodulatory Functions of Human Mesenchymal Stromal Cells are Enhanced When Cultured on HEP/COL Multilayers Supplemented with Interferon-gamma, Mahsa Letter-Mahsa Haseli, David A. Castilla-Casadiego, Luis Carlos Pinzon-Herrera, Alexander Hillsley, Katherine A. Miranda-Munoz, Srikanth Sivaraman, Adrianne M. Rosales, Raj R. Rao, and Jorge Almodovar
Process- and Product-Related Foulants in Virus Filtration, Solomon Isu, Xianghong Qian, Andrew L. Zydney, and S. Ranil Wickramasinghe
Engineered FGF1 and FGF2 compositions and methods of use thereof, Thallapuranam Krishnaswamy Suresh Kumar, Shilpi Agarwal, Ravi Kumar Gundampati, Srinivas Jayanthi, Tengjiao Wang, Jake Jones, Olivia Kolenc, Ngoc Thien Lam, Isabelle Ishimwe Niyonshuti, Kartik Balachandran, Kyle Quinn, and Jingyi Chen
Development of Custom Wall-Less Cardiovascular Flow Phantoms with Tissue-Mimicking Gel, Megan Laughlin, Sam E. Stephens, Jamie A. Hestekin, and Morten O. Jensen
Raman Spectroscopy Reveals Phenotype Switches in Breast Cancer Metastasis, Santosh Kumar Paidi, Joel Rodriguez Troncoso, Mason G. Harper, Zhenhui Liu, Khue G. Nguyen, Sruthi Ravindranathan, Lisa Rebello, David E. Lee, Jesse D. Ivers, David A. Zaharoff, Narasimhan Rajaram, and Ishan Barman
Development of an Integrated Salt Cartridge-Reverse Electrodialysis (Red) Device to Increase Electrolyte Concentrations to Biomedical Devices, Efecan Pakkaner, Jessica L. Orton, Caroline G. Campbell, Jamie A. Hestekin, and Christa N. Hestekin
Novel Neurostimulation-Based Haptic Feedback Platform for Grasp Interactions With Virtual Objects, Aliyah K. Shell, Andres E. Pena, James J. Abbas, and Ranu Jung
In Vitro Mitral Valve Model with Unrestricted Ventricular Access: Using Vacuum to Close the Valve and Enable Static Trans-Mitral Pressure, Sam E. Stephens, Alexander J. Kammien, Jacob C. Paris, Alexis P. Applequist, Neil B. Ingels, Hanna K. Jensen, Drew E. Rodgers, Charles R. Cole, Jonathan F. Wenk, and Morten O. Jensen
Incorporating Immersive Learning into Biomedical Engineering Laboratories Using Virtual Reality, Megan Wilkerson, Vitali V. Maldonado, Srikanth Sivaraman, Raj R. Rao, and Mostafa Elsaadany
In Vitro Blood Clot Formation and Dissolution for Testing New Stroke-Treatment Devices, Kayla Wood, Sam E. Stephens, Feng Xu, Alshaimaa Hazaa, James C. Meek, Hanna K. Jensen, Morten O. Jensen, and S. Ranil Wickramasinghe
