Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance

Authors

Oshadi Edirisinghe, University of Arkansas, FayettevilleFollow
Gaetane Ternier, University of Arkansas, Fayetteville
Zeina Alraawi, University of Arkansas, FayettevilleFollow
Thallapuranam Krishnaswamy Suresh Kumar, University of Arkansas, FayettevilleFollow

Document Type

Article

Publication Date

12-2024

Keywords

Fibroblast Growth Factors; FGF; FGF receptor; FGF signaling; mitogens; FGF pathology

Abstract

Fibroblast Growth Factors (FGFs) and their cognate receptors, FGFRs, play pivotal roles in a plethora of biological processes, including cell proliferation, differentiation, tissue repair, and metabolic homeostasis. This review provides a comprehensive overview of FGF-FGFR signaling pathways while highlighting their complex regulatory mechanisms and interconnections with other signaling networks. Further, we briefly discuss the FGFs involvement in developmental, metabolic, and housekeeping functions. By complementing current knowledge and emerging research, this review aims to enhance the understanding of FGF-FGFR-mediated signaling and its implications for health and disease, which will be crucial for therapeutic development against FGF-related pathological conditions.

Citation

Edirisinghe, O., Ternier, G., Alraawi, Z., & Kumar, T. K. (2024). Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance. Biomolecules, 14 (12), 1622. https://doi.org/10.3390/biom14121622

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.