Date of Graduation

5-2016

Document Type

Thesis

Degree Name

Bachelor of Science

Degree Level

Undergraduate

Department

Health, Human Performance and Recreation

Advisor/Mentor

McDermott, Brendon P.

Committee Member/Reader

Washington, Tyrone

Committee Member/Second Reader

Gray, Michelle

Abstract

Purpose: The purpose of this study was to evaluate patient-centered outcomes of functional capability and pain levels following Autologous Chondrocyte Implantation (ACI) surgery, as well as compare results from previous studies. Research was also conducted to find possible predictors of short-term success following ACI surgery. Methods: 10 patients (43 ± 6 years) were asked to complete a survey packet pre-operatively, and at three, six, and 12 months post-surgery as part of their standard medical files. These surveys included the International Knee Documentation Committee (IKDC), Visual Analog Scale (VAS) for pain, Depression Self-assessment (DSA), and a Global Rating of Change (GROC) for overall functional ability. Scores were reviewed from each survey and entered into an excel data sheet. All variables were analyzed with descriptive statistics and percentages of patients were calculated. Select variables were analyzed using paired samples t-tests. Receiver operator characteristic curve analysis was conducted to determine cut points for select variables as potential predictors of successful outcome. To determine clinically relevant outcomes and predictive value, further 2X2 cross tabulation analysis was used to calculate sensitivity, specificity, and relative risk ratios. Results: Data collected at 2.7 ± 0.9 months post-operation indicated an 80% short-term success rate. Success rates were determined by GROC score ≥3 or post-VAS pain levels ≤2. A decrease in VAS pain levels was similar to previous studies, while a decrease in IKDC scores was not comparable. Patients with pre-operative VAS scores ≥3, pre-IKDC scores <50, DSA score ≤7, and patients ≥40 years were found to have a greater chance of having a post-GROC of ≥3. Patients <40 years were found to have a greater chance of experiencing pain levels ≤2. Conclusion: Short-term results suggest that the ACI procedure does produce short-term success; however, more long-term data is needed to establish further success rates.

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