Document Type

Patent

Publication Date

3-5-2019

Abstract

Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.

Department

Biological Sciences; Physics

Patent Number

US10220000

Application Number

US 20180104188 A1

Application Published

4-19-2018

Application Filed

12-19-2017

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR); BioVentures, LLC (Little Rock, AR)

Comments

Henry, Ralph, Department of Biological Sciences, University of Arkansas, Fayetteville, AR

Salamo, Greg J., Department of Physics, University of Arkansas, Fayetteville, AR

Mazur, Yuriy, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR

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