Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.
Biological Sciences; Physics
US 20180104188 A1
Board of Trustees of the University of Arkansas (Little Rock, AR); BioVentures, LLC (Little Rock, AR)
Fologea, Daniel; Henry, Ralph; Salamo, Greg J.; Mazur, Yuriy; and Borrelli, Michael J., "Methods and compositions for X-ray induced release from pH sensitive liposomes" (2019). Patents Granted. 355.