Document Type
Patent
Publication Date
3-5-2019
Abstract
Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.
Department
Biological Sciences; Physics
Patent Number
US10220000
Application Number
US 20180104188 A1
Application Published
4-19-2018
Application Filed
12-19-2017
Assignee
Board of Trustees of the University of Arkansas (Little Rock, AR); BioVentures, LLC (Little Rock, AR)
Citation
Fologea, D., Henry, R., Salamo, G. J., Mazur, Y., & Borrelli, M. J. (2019). Methods and compositions for X-ray induced release from pH sensitive liposomes. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/355
Comments
Daniel Fologea, Department of Physics, University of Arkansas, Fayetteville, AR
Ralph Henry, Department of Biological Sciences, University of Arkansas, Fayetteville, AR
Greg J. Salamo, Department of Physics, University of Arkansas, Fayetteville, AR
Yuriy Mazur, Institute for Nanoscience and Engineering, University of Arkansas, Fayetteville, AR