Document Type

Patent

Publication Date

3-22-2022

Abstract

Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. In these methods, the therapeutic agent is not a PTH/PTHrP receptor agonist or antagonist, basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). The bacterial collagen-binding polypeptide segment delivers the agent to sites of partially untwisted or under-twisted collagen. Methods of treating collagenopathies using a composition including a collagen-binding polypeptide and a PTH/PTHrP receptor agonist are also provided. In addition, methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. Finally, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.

Department

Chemistry & Biochemistry

Patent Number

US11279922

Application Number

US 20190249163 A1

Application Published

8-15-2019

Application Filed

2-22-2019

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR); Kitasato Institute (Tokyo, JP); Montefiore Medical Center (New York, NY); National University Corporation Kagawa University (Kagawa, JP)

Comments

Joshua Sakon, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

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