Engineered FGF1 and FGF2 compositions and methods of use thereof

Inventors

Thallapuranam Krishnaswamy Suresh Kumar, University of Arkansas, FayettevilleFollow
Shilpi Agarwal, University of Arkansas, Fayetteville
Ravi Kumar Gundampati, University of Arkansas, Fayetteville
Srinivas Jayanthi, University of Arkansas, FayettevilleFollow
Tengjiao Wang, University of Arkansas, FayettevilleFollow
Jake Jones, University of Arkansas, FayettevilleFollow
Olivia Kolenc, University of Arkansas, Fayetteville
Ngoc Thien Lam, University of Arkansas, FayettevilleFollow
Isabelle Ishimwe Niyonshuti, University of Arkansas, FayettevilleFollow
Kartik Balachandran, University of Arkansas, FayettevilleFollow
Kyle Quinn, University of Arkansas, FayettevilleFollow
Jingyi Chen, University of Arkansas, FayettevilleFollow

Document Type

Patent

Publication Date

3-8-2022

Abstract

Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.

Department

Biological Sciences; Biomedical Engineering; Chemistry & Biochemistry

Patent Number

US11267855

Application Number

US 20190284252 A1

Application Published

9-19-2019

Application Filed

3-18-2019

Assignee

Board of Trustees of the University of Arkansas (Little Rock, AR)

Comments

Thallapuranam Krishnaswamy Suresh Kumar, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Shilpi Agarwal, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Ravi Kumar Gundampati, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Srinivas Jayanthi, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Tengjiao Wang, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Jake Jones, Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR
Olivia Kolenc, Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR
Ngoc T. Lam, Department of Biological Sciences, University of Arkansas, Fayetteville, AR
Isabelle I. Niyonshuti, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR
Kartik Balachandran, Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR
Kyle Quinn, Department of Biomedical Engineering, University of Arkansas, Fayetteville, AR
Jingyi Chen, Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR

Citation

Kumar, T., Agarwal, S., Gundampati, R. K., Jayanthi, S., Wang, T., Jones, J., Kolenc, O., Lam, N. T., Niyonshuti, I. I., Balachandran, K., Quinn, K., & Chen, J. (2022). Engineered FGF1 and FGF2 compositions and methods of use thereof. Patents Granted. Retrieved from https://scholarworks.uark.edu/pat/433