Characterization of an Acetogenin-Carrying Nanosuspension and Its Effect on Bacteria of Interest in the Poultry Industry

Authors

• Brandon A. Lopez-Romero, Instituto Tecnologico de Tepic
• Gabriela Aguilar-Hernandez, Centro Universitario de los Altos
• Billy Hargis, University of Arkansas, FayettevilleFollow
• Maria de Lourdes Garcia-Magana, Instituto Tecnologico de Tepic
• Ulises M. Lopez-Garcia, Instituto Tecnologico de Tepic
• Rosa I. Ortiz-Basurto, Instituto Tecnologico de Tepic
• Adalberto Zamudio-Ojeda, Universidad de Guadalajara
• Juan D. Latorre, University of Arkansas, FayettevilleFollow
• Efigenia Montalvo-Gonzalez, Instituto Tecnologico de Tepic

Document Type

Article

Publication Date

1-2025

Keywords

acetogenins, antibacterial activity, nanosuspensions, poultry sector

Abstract

This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-beta-cyclodextrin (beta CD) named NSps-beta CDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-beta CDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-beta CDSL-ACGs presented nanometric size (207-239 nm), acceptable polydispersity index (PDI) values (0.13-0.17) and a high Z potential value (-47.17-50.36 mV), demonstrating high stability. The presence of ACGs in NSps-beta CDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical shape and exhibited high inhibition potential against Salmonella Enteritidis (88.18%), Streptococcus gallolyticus (88.01%), Salmonella Typhimurium (86.28%) and Salmonella Infantis (77.02%) strains up to 48 h, and a reduction of up to 3 log CFU/mL was achieved for S. Typhimurium. Therefore, NSps-beta CDSL-ACGs is an attractive option for implementing ACGs administration in the poultry sector to reduce the use of antibiotics and minimize bacterial resistance.

Comments

Web of Science

MDPI

Citation

López-Romero, B.A.; Aguilar-Hernández, G.; Hargis, B.M.; García-Magaña, M.d.L.; López-García, U.M.; Ortiz-Basurto, R.I.; Zamudio-Ojeda, A.; Latorre, J.D.; Montalvo-González, E. Characterization of an Acetogenin-Carrying Nanosuspension and Its Effect on Bacteria of Interest in the Poultry Industry. Microorganisms 2025, 13, 18. https://doi.org/10.3390/microorganisms13010018

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.