Date of Graduation

5-2022

Document Type

Thesis

Degree Name

Bachelor of Science in Biomedical Engineering

Degree Level

Undergraduate

Department

Biomedical Engineering

Advisor/Mentor

Jensen, Morten

Committee Member/Reader

Quinn, Kyle

Abstract

According to the CDC, nearly 800,000 individuals experience stroke each year in the United States [1]. Greater than 70% of strokes are of ischemic etiology and involve the occlusion of key arteries in the cardiovascular system [2]. Tissue plasminogen activator (IV-tPA) is the current gold standard for thrombolytic approaches [3]; however, this therapeutic is only effective between 3 and 4.5 hours from the patient’s last know well [4]. As a result, less than 5% of acute ischemic stroke patients receive IV-tPA. In order to increase the viability of AIS treatment as a whole, it is essential that thrombolytic techniques are combined with recanalization methods – so that the individuals unable to present to the emergency department during the treatment window still have options. The proposed device aims to decrease exposure to ischemia and increase the viability of reperfusion by combining precedent with novelty. The study seeks to show the potential for benchtop laboratory modeling of blood clots and plasmin using gelatin and bleach respectively.

Keywords

Acute ischemic stroke; thrombolysis; recanalization methods

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